Politicial observers and some Turks say the outcome of the vote could be critical, not only for Turkey-U.S. relations ,but also the recent rapprochement between Turkey and Armenia.
The draft, to be voted on by the 46 members committee, calls on U-S President Barack Obama to recognise the tragic events of 19-15 as "genocide".
The draft resolution was proposed by Democrats and two Republicans.
Critics say they are all important figures for the Armenian lobby in the U-S.
Turkey strongly rejects the genocide allegations.
Turkey regards the deaths of hundreds of thousands of Armenians, during World War One, as events of civil strife in wartime, which claimed the lives of many Turks and Armenians.
Every year between March 4th and April 24th alarm bells ring for relations between Turkey and U-S.
Turkish officials say Armenian lobbies pressure the U-S legislators to pass a resolution, urging the President to recognise the 19-15 events as "genocide".
Turkish lawmakers and officials visit to U-S House and hold meetings with senior U-S officials and businessleaders to prevent the resolution from being adopted.
If the resolution is adopted, it will then be sent to the full House of Representatives for a vote.
In 2007, a similar resolution was adopted with 27 seven votes for it and 21 against it.
Former President George W. Bush intervened to prevent the the resolution from being brought to the House floor.
Even if the resolution is adopted both in the Committee and by the full House, it is not binding on the Obama administration.
However, it will show U-S lawmakers are sensitive about the issue.